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KMID : 1123920190330060349
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Korean Journal of Oriental Physiology and Pathology
2019 Volume.33 No. 6 p.349 ~ p.356
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Anti-oxidative and Whitening Efects of 4’-O-methylalpinumisoflavone Isolated from Fruit of Maclura Tricuspidata Carriere
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Lyu Ji-Hyo
Noh Joon-Yong
Kim Su-Ra
Lee Guem-San
Lee Dong-Ho
Kim Koan-hoi
Kim Hyung-Woo
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Abstract
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The anti-inflammatory effects of 4’?O?methylalpinumisoflavone (OMAI) has been reported in recent years. To develop effective and safe skin whitening agents, we investigated the anti-oxidative and melanogenic effects of OMAI isolated from fruit of Maclura tricuspidata Carriere (Cudrania tricuspidata) in macrophage and melanoma cell lines. In our results, OMAI showed effective superoxide scavenging activity and suppressed production of lipopolysaccharide (LPS)-induced intracellular reactive oxygen species (ROS) in RAW264.7 cells. In addition, α-melanocyte stimulation hormone (MSH)-induced production of melanin was also reduced by OMAI in B16F10 cells. Finally, OMAI significantly inhibited tyrosinase activity in B16F10 cells. These results suggest that OMAI suppressed melanin production via scavenging reactive oxygen species and inhibition of tyrosinase activity.
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KEYWORD
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Maclura tricuspidata, 4’-O-methylalpinumisoflavone, Anti-oxidant, Melanin, Tyrosinase
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